| First Author | Fratzl A | Year | 2021 |
| Journal | Neuron | Volume | 109 |
| Issue | 23 | Pages | 3810-3822.e9 |
| PubMed ID | 34614420 | Mgi Jnum | J:325342 |
| Mgi Id | MGI:6877243 | Doi | 10.1016/j.neuron.2021.09.003 |
| Citation | Fratzl A, et al. (2021) Flexible inhibitory control of visually evoked defensive behavior by the ventral lateral geniculate nucleus. Neuron 109(23):3810-3822.e9 |
| abstractText | Animals can choose to act upon, or to ignore, sensory stimuli, depending on circumstance and prior knowledge. This flexibility is thought to depend on neural inhibition, through suppression of inappropriate and disinhibition of appropriate actions. Here, we identified the ventral lateral geniculate nucleus (vLGN), an inhibitory prethalamic area, as a critical node for control of visually evoked defensive responses in mice. The activity of vLGN projections to the medial superior colliculus (mSC) is modulated by previous experience of threatening stimuli, tracks the perceived threat level in the environment, and is low prior to escape from a visual threat. Optogenetic stimulation of the vLGN abolishes escape responses, and suppressing its activity lowers the threshold for escape and increases risk-avoidance behavior. The vLGN most strongly affects visual threat responses, potentially via modality-specific inhibition of mSC circuits. Thus, inhibitory vLGN circuits control defensive behavior, depending on an animal's prior experience and its anticipation of danger in the environment. |
