| First Author | Jeong H | Year | 2024 |
| Journal | Dev Cell | PubMed ID | 39642880 |
| Mgi Jnum | J:360668 | Mgi Id | MGI:7798679 |
| Doi | 10.1016/j.devcel.2024.11.007 | Citation | Jeong H, et al. (2024) Microbiota-derived short-chain fatty acids determine stem cell characteristics of gastric chief cells. Dev Cell |
| abstractText | The gastric mucosa is a highly dynamic tissue that undergoes constant self-renewal through stem cell differentiation. Chief cells maintain a quiescent state in homeostasis but are responsible for regeneration after injury. Although the role of microbiome-host interactions in the intestine is well studied, less is known about these interactions in the stomach. Using the mouse organoid and germ-free mouse models, we show that microbiota-derived short-chain fatty acids (SCFAs) suppress the proliferation of chief cells in mice. This effect is mediated by activation of G-protein-coupled receptor 43. Most importantly, through metabolomics and transplantation studies, we show butyrate-producing Lactobacillus intestinalis modulates the proliferation of chief cells in mice. Our findings identify a mechanism by which the microbiota regulates the cell characteristics of chief cells, providing insight into the complex interplay between the host and its microbial environment and the mechanisms underlying gastric homeostasis, with potential therapeutic implications for gastric diseases. |
