| First Author | Füzesi T | Year | 2023 |
| Journal | Nat Commun | Volume | 14 |
| Issue | 1 | Pages | 8522 |
| PubMed ID | 38129411 | Mgi Jnum | J:352809 |
| Mgi Id | MGI:7568356 | Doi | 10.1038/s41467-023-44163-5 |
| Citation | Fuzesi T, et al. (2023) Hypothalamic CRH neurons represent physiological memory of positive and negative experience. Nat Commun 14(1):8522 |
| abstractText | Recalling a salient experience provokes specific behaviors and changes in the physiology or internal state. Relatively little is known about how physiological memories are encoded. We examined the neural substrates of physiological memory by probing CRH(PVN) neurons of mice, which control the endocrine response to stress. Here we show these cells exhibit contextual memory following exposure to a stimulus with negative or positive valence. Specifically, a negative stimulus invokes a two-factor learning rule that favors an increase in the activity of weak cells during recall. In contrast, the contextual memory of positive valence relies on a one-factor rule to decrease activity of CRH(PVN) neurons. Finally, the aversive memory in CRH(PVN) neurons outlasts the behavioral response. These observations provide information about how specific physiological memories of aversive and appetitive experience are represented and demonstrate that behavioral readouts may not accurately reflect physiological changes invoked by the memory of salient experiences. |
