| First Author | Krone LB | Year | 2021 |
| Journal | Nat Neurosci | Volume | 24 |
| Issue | 9 | Pages | 1210-1215 |
| PubMed ID | 34341585 | Mgi Jnum | J:324024 |
| Mgi Id | MGI:7263122 | Doi | 10.1038/s41593-021-00894-6 |
| Citation | Krone LB, et al. (2021) A role for the cortex in sleep-wake regulation. Nat Neurosci 24(9):1210-1215 |
| abstractText | Cortical and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global state control, respectively. Here we silenced a subset of neocortical layer 5 pyramidal and archicortical dentate gyrus granule cells in male mice by ablating SNAP25. This markedly increased wakefulness and reduced rebound of electroencephalographic slow-wave activity after sleep deprivation, suggesting a role for the cortex in both vigilance state control and sleep homeostasis. |
