| First Author | Fan LZ | Year | 2023 |
| Journal | Cell | Volume | 186 |
| Issue | 3 | Pages | 543-559.e19 |
| PubMed ID | 36669484 | Mgi Jnum | J:352913 |
| Mgi Id | MGI:7432233 | Doi | 10.1016/j.cell.2022.12.035 |
| Citation | Fan LZ, et al. (2023) All-optical physiology resolves a synaptic basis for behavioral timescale plasticity. Cell 186(3):543-559.e19 |
| abstractText | Learning has been associated with modifications of synaptic and circuit properties, but the precise changes storing information in mammals have remained largely unclear. We combined genetically targeted voltage imaging with targeted optogenetic activation and silencing of pre- and post-synaptic neurons to study the mechanisms underlying hippocampal behavioral timescale plasticity. In mice navigating a virtual-reality environment, targeted optogenetic activation of individual CA1 cells at specific places induced stable representations of these places in the targeted cells. Optical elicitation, recording, and modulation of synaptic transmission in behaving mice revealed that activity in presynaptic CA2/3 cells was required for the induction of plasticity in CA1 and, furthermore, that during induction of these place fields in single CA1 cells, synaptic input from CA2/3 onto these same cells was potentiated. These results reveal synaptic implementation of hippocampal behavioral timescale plasticity and define a methodology to resolve synaptic plasticity during learning and memory in behaving mammals. |
