| First Author | Siwani S | Year | 2018 |
| Journal | Neuron | Volume | 99 |
| Issue | 2 | Pages | 404-412.e3 |
| PubMed ID | 29983324 | Mgi Jnum | J:269527 |
| Mgi Id | MGI:6269012 | Doi | 10.1016/j.neuron.2018.06.022 |
| Citation | Siwani S, et al. (2018) OLMalpha2 Cells Bidirectionally Modulate Learning. Neuron 99(2):404-412.e3 |
| abstractText | Inhibitory interneurons participate in mnemonic processes. However, defined roles for identified interneuron populations are scarce. A subpopulation of oriens lacunosum-moleculare (OLM) interneurons genetically defined by the expression of the nicotinic receptor alpha2 subunit has been shown to gate information carried by either the temporoammonic pathway or Schaffer collaterals in vitro. Here we set out to determine whether selective modulation of OLMalpha2 cells in the intermediate CA1 affects learning and memory in vivo. Our data show that intermediate OLMalpha2 cells can either enhance (upon their inhibition) or impair (upon their activation) object memory encoding in freely moving mice, thus exerting bidirectional control. Moreover, we find that OLMalpha2 cell activation inhibits fear-related memories and that OLMalpha2 cells respond differently to nicotine in the dorsoventral axis. These results suggest that intermediate OLMalpha2 cells are an important component in the CA1 microcircuit regulating learning and memory processes. VIDEO ABSTRACT. |
