| First Author | Wu YT | Year | 2022 |
| Journal | Cell Rep | Volume | 39 |
| Issue | 12 | Pages | 110978 |
| PubMed ID | 35732133 | Mgi Jnum | J:347508 |
| Mgi Id | MGI:7314086 | Doi | 10.1016/j.celrep.2022.110978 |
| Citation | Wu YT, et al. (2022) Quantitative relationship between cerebrovascular network and neuronal cell types in mice. Cell Rep 39(12):110978 |
| abstractText | The cerebrovasculature and its mural cells must meet brain regional energy demands, but how their spatial relationship with different neuronal cell types varies across the brain remains largely unknown. Here we apply brain-wide mapping methods to comprehensively define the quantitative relationships between the cerebrovasculature, capillary pericytes, and glutamatergic and GABAergic neurons, including neuronal nitric oxide synthase-positive (nNOS(+)) neurons and their subtypes in adult mice. Our results show high densities of vasculature with high fluid conductance and capillary pericytes in primary motor sensory cortices compared with association cortices that show significant positive and negative correlations with energy-demanding parvalbumin(+) and vasomotor nNOS(+) neurons, respectively. Thalamo-striatal areas that are connected to primary motor sensory cortices also show high densities of vasculature and pericytes, suggesting dense energy support for motor sensory processing areas. Our cellular-resolution resource offers opportunities to examine spatial relationships between the cerebrovascular network and neuronal cell composition in largely understudied subcortical areas. |
