| First Author | Ford MJ | Year | 2023 |
| Journal | Biol Open | Volume | 12 |
| Issue | 9 | PubMed ID | 37605939 |
| Mgi Jnum | J:340729 | Mgi Id | MGI:7530071 |
| Doi | 10.1242/bio.059963 | Citation | Ford MJ, et al. (2023) CD133/Prom1 marks proximal mouse oviduct epithelial progenitors and adult epithelial cells with a low generative capacity. Biol Open 12(9) |
| abstractText | The epithelium lining the oviduct or fallopian tube consists of multiciliated and secretory cells, which support fertilization and preimplantation development, however, its homeostasis remains poorly understood. CD133/Prom1 expression has been used as a marker to identify adult stem cell populations in various organs and often associated with cancer cells that have stem-like properties. Using an antibody targeted to CD133 and a Cre recombinase-based lineage tracing strategy, we found that CD133/Prom1 expression is not associated with a stem/progenitor population in the oviduct but marked predominantly multiciliated cells with a low generative capacity. Additionally, we have shown that CD133 is disparately localised along the oviduct during neonatal development, and that Prom1 expressing secretory cells in the ampulla rapidly transitioned to multiciliated cells and progressively migrated to the ridge of epithelial folds. |
