| First Author | Zhao F | Year | 2018 |
| Journal | Exp Eye Res | Volume | 170 |
| Pages | 169-176 | PubMed ID | 29501382 |
| Mgi Jnum | J:265090 | Mgi Id | MGI:6199357 |
| Doi | 10.1016/j.exer.2018.02.026 | Citation | Zhao F, et al. (2018) Expression, regulation and function of miR-126 in the mouse choroid vasculature. Exp Eye Res 170:169-176 |
| abstractText | MicroRNA miR-126 has been shown to be required for proper angiogenesis in several models. However, its expression, regulation and function in the mouse choroid remain unclear. Our previous data has shown that miR-126 expression is enriched in the endothelial cells (ECs) of the mouse choroid. Here we report that a 5.5kb Egfl7/miR-126 promoter drives the expression of miR-126 in the choroid ECs during choroidal vascular development. The expression of miR-126 in the ECs is regulated by flow stress likely through Kruppel-like transcriptional factors. miR-126(-/-) mice show mildly delayed choroidal vascular development, but adult knockout mice develop periphery choroidal vascular lesions. This study suggests that miR-126 is largely dispensable for mouse choroidal development but required for maintaining choroidal vasculature integrity. |
