| First Author | Zhu PJ | Year | 2018 |
| Journal | Nat Neurosci | Volume | 21 |
| Issue | 6 | Pages | 799-802 |
| PubMed ID | 29786082 | Mgi Jnum | J:264740 |
| Mgi Id | MGI:6196767 | Doi | 10.1038/s41593-018-0156-7 |
| Citation | Zhu PJ, et al. (2018) mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors. Nat Neurosci 21(6):799-802 |
| abstractText | The mechanistic target of rapamycin complex 1 (mTORC1) has been reported to be necessary for metabotropic glutamate receptor-mediated long-term depression (mGluR-LTD). Here we found that mTORC1-deficient mice exhibit normal hippocampal mGluR-LTD and associated behaviors. Moreover, rapamycin blocks mGluR-LTD in mTORC1-deficient mice. However, both rapamycin and mGluR activation regulate mTOR complex 2 (mTORC2) activity, and mTORC2-deficient mice show impaired mGluR-LTD and associated behaviors. Thus, mTORC2 is a major regulator of mGluR-LTD. |
