| Primary Identifier | MGI:3811745 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Nct2 |
| Transmission | Germline | Strain of Origin | (C57BL/6J x 129X1/SvJ)F1 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A loxP-flanked neomycin selection cassette replaced the entire coding sequence of the two gene loci. PicoRNAs (piRNA) from the gene loci were not detectable by real-time PCR on RNA from the testes of homozygous mice. Also, piRNAs up to 7 kb upstream (piR-135965) and 8 kb downstream of the deleted region (piR-111581) were markedly decreased in the testes of male homozygotes. Expression of the L1 retrotransposon, a target of some of these piRNAs, was increased in the testes of these mice. |
