| First Author | McRory JE | Year | 2008 |
| Journal | Biochem Biophys Res Commun | Volume | 375 |
| Issue | 3 | Pages | 372-7 |
| PubMed ID | 18713622 | Mgi Jnum | J:141037 |
| Mgi Id | MGI:3815271 | Doi | 10.1016/j.bbrc.2008.08.031 |
| Citation | McRory JE, et al. (2008) Syntaxin 1A is required for normal in utero development. Biochem Biophys Res Commun 375(3):372-7 |
| abstractText | We have generated a syntaxin 1A knockout mouse by deletion of exons 3 through 6 and a concomitant insertion of a stop codon in exon 2. Heterozygous knockout animals were viable with no apparent phenotype. In contrast, the vast majority of homozygous animals died in utero, with embryos examined at day E15 showing a drastic reduction in body size and development when compared to WT and heterozygous littermates. Surprisingly, out of a total of 204 offspring from heterozygous breeding pairs only four homozygous animals were born alive and viable. These animals exhibited reduced body weight, but showed only mild behavioral deficiencies. Taken together, our data indicate that syntaxin 1A is an important regulator of normal in utero development, but may not be essential for normal brain function later in life. |
