| First Author | Torti N | Year | 2011 |
| Journal | Eur J Immunol | Volume | 41 |
| Issue | 9 | Pages | 2612-8 |
| PubMed ID | 21604258 | Mgi Jnum | J:176829 |
| Mgi Id | MGI:5292798 | Doi | 10.1002/eji.201041075 |
| Citation | Torti N, et al. (2011) Batf3 transcription factor-dependent DC subsets in murine CMV infection: Differential impact on T-cell priming and memory inflation. Eur J Immunol 41(9):2612-8 |
| abstractText | Priming of CD8(+) T cells specific for viruses that interfere with the MHC class I presentation pathway is a challenge for the immune system and is believed to rely on cross-presentation. Cytomegalovirus (CMV) infection induces vigorous CD8(+) T-cell responses despite its potent immune evasion strategies. Furthermore, CD8(+) T cells specific for a subset of viral epitopes accumulate and are maintained at high levels exhibiting an activated phenotype - referred to as 'inflationary T cells'. Taking advantage Batf3(-/-) mice in which the development of cross-presenting CD8alpha(+) and CD103(+) DCs is severely compromised, we analyzed their role in the induction and inflation of murine (M)CMV-specific CD8(+) T-cell responses. We found that priming of MCMV-specific CD8(+) T cells was severely impaired in the absence of cross-presenting DCs. However, inflation of two immuno-dominant MCMV-specific CD8(+) T-cell populations was largely normal in the absence of cross-presenting DCs, indicating that inflation during latency was mainly dependent on direct antigen presentation. These results highlight differential antigen presentation requirements during acute and latent MCMV infection. |
