| First Author | Zhao J | Year | 2024 |
| Journal | Dev Dyn | Volume | 253 |
| Issue | 1 | Pages | 144-156 |
| PubMed ID | 36004502 | Mgi Jnum | J:344097 |
| Mgi Id | MGI:7571631 | Doi | 10.1002/dvdy.530 |
| Citation | Zhao J, et al. (2024) Maternal and zygotic ZFP57 regulate coronary vascular formation and myocardium maturation in mouse embryo. Dev Dyn 253(1):144-156 |
| abstractText | BACKGROUND: Genomic and epigenomic dynamics both play critical roles during embryogenesis. Zfp57 maintains genomic imprinting with both maternal and zygotic functions. In our previous study, we found that maternal and zygotic Zfp57 modulate NOTCH signaling during cardiac development. In this study, we investigated Zfp57 mutants from E11.5 to E13.5 to delineate its function during cardiac development. RESULTS: Here, we describe novel roles of maternal and zygotic Zfp57 during cardiovascular system development. We found that maternal and zygotic Zfp57 was required for coronary vascular development. Maternal and zygotic loss of Zfp57 perturbed the sprouting of the sinus venosus-derived endothelial cells and led to underdeveloped coronary vasculature, meanwhile, there was an ectopic overproduction of blood islands over the ventricles. Furthermore, loss of Zfp57 and failed vasculature disturbed myocardium maturation. Loss of maternal and zygotic Zfp57 resulted in hyper trabeculation and failed myocardium compaction. Zfp57 zygotic mutant (M(+) Z(-) ) hearts displayed noncompaction cardiomyopathy at E18.5. CONCLUSIONS: Our results suggest that maternal and zygotic ZFP57 are essential for coronary vascular formation and myocardium maturation in mice. Our research provides evidence for the role of genomic imprinting during embryogenesis. |
