| First Author | Moreau JM | Year | 2017 |
| Journal | PLoS One | Volume | 12 |
| Issue | 9 | Pages | e0185509 |
| PubMed ID | 28957409 | Mgi Jnum | J:250359 |
| Mgi Id | MGI:5921887 | Doi | 10.1371/journal.pone.0185509 |
| Citation | Moreau JM, et al. (2017) Bone marrow basophils provide survival signals to immature B cells in vitro but are dispensable in vivo. PLoS One 12(9):e0185509 |
| abstractText | Immature B cells are the first B cell progenitors to express a fully formed B cell receptor and are therefore subject to extensive selection processes that act to mitigate the emergence of autoreactive clones. While it is well appreciated that most B cell generation in the bone marrow is highly dependent on access to molecules present in the local milieu, the existence of extrinsically provided factors that modulate immature B cell biology is ambiguous. Nonetheless, a population of CD49b+CD90lo cells has demonstrated in vitro potential to promote immature B cell survival. Using a mouse basophil reporter strain we confirmed the identity of these CD49b+CD90lo supportive cells as basophils. However, analysis of bone marrow B cell populations following lineage specific basophil depletion demonstrates that basophils do not have a significant role in vivo in modulating immature B cell biology during steady-state conditions. |
