| First Author | Conte D | Year | 2006 |
| Journal | Mol Cell Biol | Volume | 26 |
| Issue | 2 | Pages | 699-708 |
| PubMed ID | 16382159 | Mgi Jnum | J:144012 |
| Mgi Id | MGI:3829587 | Doi | 10.1128/MCB.26.2.699-708.2006 |
| Citation | Conte D, et al. (2006) Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival. Mol Cell Biol 26(2):699-708 |
| abstractText | The cellular inhibitor of apoptosis 2 (cIAP2/HIAP1) is a potent inhibitor of apoptotic death. In contrast to the other members of the IAP family, cIAP2 is transcriptionally inducible by nuclear factor-kappaB in response to multiple triggers. We demonstrate here that cIAP2-/- mice exhibit profound resistance to lipopolysaccharide (LPS)-induced sepsis, specifically because of an attenuated inflammatory response. We show that LPS potently upregulates cIAP2 in macrophages and that cIAP2-/- macrophages are highly susceptible to apoptosis in a LPS-induced proinflammatory environment. Hence, cIAP2 is critical in the maintenance of a normal innate immune inflammatory response. |
