| Primary Identifier | MGI:3829607 | Allele Type | Targeted |
| Attribute String | Hypomorph | Gene | Runx2 |
| Transmission | Germline | Strain of Origin | 129S7/SvEvBrd-Hprt1<b-m2> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A floxed neo cassette was inserted into intron 7. The retention of the neo cassette results in a 55% to 70% decrease in relative full-length transcript expression in homozygotes and a 79% to 84% decrease in heterozygotes. Expression of a truncated transcript was observed, and reduced protein expression was confirmed by western blot analysis. |
