| First Author | Bannard O | Year | 2009 |
| Journal | Science | Volume | 323 |
| Issue | 5913 | Pages | 505-9 |
| PubMed ID | 19164749 | Mgi Jnum | J:144174 |
| Mgi Id | MGI:3830394 | Doi | 10.1126/science.1166831 |
| Citation | Bannard O, et al. (2009) Secondary replicative function of CD8+ T cells that had developed an effector phenotype. Science 323(5913):505-9 |
| abstractText | Models of the differentiation of memory CD8+ T cells that replicate during secondary infections differ over whether such cells had acquired effector function during primary infections. We created a transgenic mouse line that permits mapping of the fate of granzyme B (gzmB)-expressing CD8+ T cells and their progeny by indelibly marking them with enhanced yellow fluorescent protein (EYFP). Virus-specific CD8+ T cells express gzmB within the first 2 days of a primary response to infection with influenza, without impairment of continued primary clonal expansion. On secondary infection, virus-specific CD8+ T cells that became EYFP+ during a primary infection clonally expand as well as all virus-specific CD8+ T cells. Thus, CD8+ T cells that have acquired an effector phenotype during primary infection may function as memory cells with replicative function. |
