| First Author | Lauron EJ | Year | 2019 |
| Journal | J Exp Med | Volume | 216 |
| Issue | 1 | Pages | 117-132 |
| PubMed ID | 30559127 | Mgi Jnum | J:273214 |
| Mgi Id | MGI:6284600 | Doi | 10.1084/jem.20181077 |
| Citation | Lauron EJ, et al. (2019) Viral MHCI inhibition evades tissue-resident memory T cell formation and responses. J Exp Med 216(1):117-132 |
| abstractText | Tissue-resident memory CD8(+) T cells (TRMs) confer rapid protection and immunity against viral infections. Many viruses have evolved mechanisms to inhibit MHCI presentation in order to evade CD8(+) T cells, suggesting that these mechanisms may also apply to TRM-mediated protection. However, the effects of viral MHCI inhibition on the function and generation of TRMs is unclear. Herein, we demonstrate that viral MHCI inhibition reduces the abundance of CD4(+) and CD8(+) TRMs, but its effects on the local microenvironment compensate to promote antigen-specific CD8(+) TRM formation. Unexpectedly, local cognate antigen enhances CD8(+) TRM development even in the context of viral MHCI inhibition and CD8(+) T cell evasion, strongly suggesting a role for in situ cross-presentation in local antigen-driven TRM differentiation. However, local cognate antigen is not required for CD8(+) TRM maintenance. We also show that viral MHCI inhibition efficiently evades CD8(+) TRM effector functions. These findings indicate that viral evasion of MHCI antigen presentation has consequences on the development and response of antiviral TRMs. |
