| First Author | Zhang S | Year | 2017 |
| Journal | In Vitro Cell Dev Biol Anim | Volume | 53 |
| Issue | 1 | Pages | 43-53 |
| PubMed ID | 27649978 | Mgi Jnum | J:239339 |
| Mgi Id | MGI:5828346 | Doi | 10.1007/s11626-016-0079-0 |
| Citation | Zhang S, et al. (2017) A potential inhibitory function of draxin in regulating mouse trunk neural crest migration. In Vitro Cell Dev Biol Anim 53(1):43-53 |
| abstractText | Draxin is a repulsive axon guidance protein that plays important roles in the formation of three commissures in the central nervous system and dorsal interneuron 3 (dI3) in the chick spinal cord. In the present study, we report the expression pattern of mouse draxin in the embryonic mouse trunk spinal cord. In the presence of draxin, the longest net migration length of a migrating mouse trunk neural crest cell was significantly reduced. In addition, the relative number of apolar neural crest cells increased as the draxin treatment time increased. Draxin caused actin cytoskeleton rearrangement in the migrating trunk neural crest cells. Our data suggest that draxin may regulate mouse trunk neural crest cell migration by the rearrangement of cell actin cytoskeleton and by reducing the polarization activity of these cells subsequently. |
