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Allele : Cacna1a<tm3Maag> calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; targeted mutation 3, Arn van den Maagdenberg
Primary Identifier  MGI:3836195 Allele Type  Targeted
Attribute String  Humanized sequence Gene  Cacna1a
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  A transition of C to T results in the amino acid substitution of serine with leucine at position 220 (p.S220L), replicating the S218L mutation found in some familial hemiplegic migraine type 1 (FHM1) patients. A loxP site flanked neomycin resistance gene cassette inserted upstream of exon 5 was removed through germ line cre-mediated recombination.
  • mutations:
  • Single point mutation,
  • Insertion
  • synonyms:
  • Cacna1a<tm1Caya>,
  • FHM-1,
  • FHM-1,
  • Cacna1a<S218L>,
  • Cacna1a<tm1Caya>,
  • Cacna1a<S218L>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

21 Publication categories

Trail: Allele




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