| First Author | Vervenne HB | Year | 2009 |
| Journal | Biochem Biophys Res Commun | Volume | 379 |
| Issue | 2 | Pages | 368-73 |
| PubMed ID | 19111675 | Mgi Jnum | J:144517 |
| Mgi Id | MGI:3831060 | Doi | 10.1016/j.bbrc.2008.12.074 |
| Citation | Vervenne HB, et al. (2009) Targeted disruption of the mouse Lipoma Preferred Partner gene. Biochem Biophys Res Commun 379(2):368-73 |
| abstractText | LPP (Lipoma Preferred Partner) is a zyxin-related cell adhesion protein that is involved in the regulation of cell migration. We generated mice with a targeted disruption of the Lpp gene and analysed the importance of Lpp for embryonic development and adult functions. Aberrant Mendelian inheritance in heterozygous crosses suggested partial embryonic lethality of Lpp(-/-) females. Fertility of Lpp(-/-) males was proven to be normal, however, females from Lpp(-/-) x Lpp(-/-) crosses produced a strongly reduced number of offspring, probably due to a combination of female embryonic lethality and aberrant pregnancies. Apart from these developmental and reproductive abnormalities, Lpp(-/-) mice that were born reached adulthood without displaying any additional macroscopic defects. On the other hand, Lpp(-/-) mouse embryonic fibroblasts exhibited reduced migration capacity, reduced viability, and reduced expression of some Lpp interaction partners. Finally, we discovered a short nuclear form of Lpp, expressed mainly in testis via an alternative promoter. |
