| Primary Identifier | MGI:3835162 | Allele Type | Targeted |
| Attribute String | Hypomorph | Gene | Socs3 |
| Transmission | Germline | Strain of Origin | B6.Cg-Thy1<a> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A 120 bp deletion of nucleotides 573-692 of the gene transcript was created in exon 2. This removes the 40 c-terminal amino acids. A floxed PGK-neomycin cassette was intruduced further downstream. The neomycin cassette was later removed by mating to transgenic Tg(CMV-cre)1Cgn mice. Immunological examination of protein extracts from liver confirmed that a truncated protein was expressed. |
