| First Author | Francis TC | Year | 2017 |
| Journal | Mol Psychiatry | Volume | 22 |
| Issue | 11 | Pages | 1512-1519 |
| PubMed ID | 28894298 | Mgi Jnum | J:249910 |
| Mgi Id | MGI:6100208 | Doi | 10.1038/mp.2017.178 |
| Citation | Francis TC, et al. (2017) Molecular basis of dendritic atrophy and activity in stress susceptibility. Mol Psychiatry 22(11):1512-1519 |
| abstractText | Molecular and cellular adaptations in nucleus accumbens (NAc) medium spiny neurons (MSNs) underlie stress-induced depression-like behavior, but the molecular substrates mediating cellular plasticity and activity in MSN subtypes in stress susceptibility are poorly understood. We find the transcription factor early growth response 3 (EGR3) is increased in D1 receptor containing MSNs of mice susceptible to social defeat stress. Genetic reduction of Egr3 levels in D1-MSNs prevented depression-like outcomes in stress susceptible mice by preventing D1-MSN dendritic atrophy, reduced frequency of excitatory input and altered in vivo activity. Overall, we identify NAc neuronal-subtype molecular control of dendritic morphology and related functional adaptations, which underlie susceptibility to stress. |
