| First Author | Chen X | Year | 2019 |
| Journal | Front Behav Neurosci | Volume | 13 |
| Pages | 110 | PubMed ID | 31139063 |
| Mgi Jnum | J:284408 | Mgi Id | MGI:6381087 |
| Doi | 10.3389/fnbeh.2019.00110 | Citation | Chen X, et al. (2019) Parvalbumin Interneurons Determine Emotional Valence Through Modulating Accumbal Output Pathways. Front Behav Neurosci 13:110 |
| abstractText | Parvalbumin (PV) expressing GABAergic interneurons provide large source of GABA to spiny projection neurons (SPNs) in the striatum. However, the roles of PV(+) interneurons in the regulation of SPNs in the ventral striatum and emotional states are largely unknown. Here, we investigated whether stimulation of ventral striatal (accumbal) PV(+) interneurons would drive emotional valence in mice. We found that during conditioned place preference (CPP) training, activation of accumbal PV(+) interneurons evoked place preference while suppressing them resulted in conditioned place aversion (CPA). Activation of PV(+) interneurons during place conditioning increased Fos expression in SPNs in the direct pathway (dSPNs) and impaired lithium chloride-induced CPA. Activation of dSPNs and SPNs in the indirect pathway (iSPNs) induced CPP and CPA, respectively; conversely, suppression of dSPNs or iSPNs induced CPA or CPP. In addition, activation or suppression of calretinin-expressing (CR) GABAergic interneurons did not induce place preference or aversion. These data suggest that PV(+) interneurons can bidirectionally determine the emotional valence through their regulation of accumbal SPN activities and raise the possibility that manipulation of PV(+) interneuron activity may have the potential to alter emotional valence and treat related mental disorders. |
