| First Author | Vélez-Fort M | Year | 2018 |
| Journal | Neuron | Volume | 98 |
| Issue | 1 | Pages | 179-191.e6 |
| PubMed ID | 29551490 | Mgi Jnum | J:260773 |
| Mgi Id | MGI:6150506 | Doi | 10.1016/j.neuron.2018.02.023 |
| Citation | Velez-Fort M, et al. (2018) A Circuit for Integration of Head- and Visual-Motion Signals in Layer 6 of Mouse Primary Visual Cortex. Neuron 98(1):179-191.e6 |
| abstractText | To interpret visual-motion events, the underlying computation must involve internal reference to the motion status of the observer''s head. We show here that layer 6 (L6) principal neurons in mouse primary visual cortex (V1) receive a diffuse, vestibular-mediated synaptic input that signals the angular velocity of horizontal rotation. Behavioral and theoretical experiments indicate that these inputs, distributed over a network of 100 L6 neurons, provide both a reliable estimate and, therefore, physiological separation of head-velocity signals. During head rotation in the presence of visual stimuli, L6 neurons exhibit postsynaptic responses that approximate the arithmetic sum of the vestibular and visual-motion response. Functional input mapping reveals that these internal motion signals arrive into L6 via a direct projection from the retrosplenial cortex. We therefore propose that visual-motion processing in V1 L6 is multisensory and contextually dependent on the motion status of the animal''s head. |
