| Primary Identifier | MGI:3837125 | Allele Type | Chemically induced (ENU) |
| Gene | Lyn | Inheritance Mode | Recessive |
| Strain of Origin | C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Enu mutagenesis caused an A to G transition at nucleotide 864 in exon 8 (GenBank accession number M57696). This converted amino acid 260 from a glutamic acid into a glycine (E260G). This amino acid is immediately C terminal to the GxGxxG G loop necessary for kinase activity for the protein. Mutant protein in homozygote B cells was expressed at slightly higher levels than endogenous protein but it lacks any detectable kinase activity. |
