| First Author | Pjetri E | Year | 2017 |
| Journal | Behav Brain Res | Volume | 332 |
| Pages | 71-74 | PubMed ID | 28559181 |
| Mgi Jnum | J:248368 | Mgi Id | MGI:5921883 |
| Doi | 10.1016/j.bbr.2017.05.051 | Citation | Pjetri E, et al. (2017) Deletion of one allele of Mthfd1 (methylenetetrahydrofolate dehydrogenase 1) impairs learning in mice. Behav Brain Res 332:71-74 |
| abstractText | The MTHFD1 gene encodes for methylenetetrahydrofolate dehydrogenase 1, an enzyme that has an important role in folate-mediated one-carbon metabolism. In people, a single nucleotide polymorphism of this gene (1958G>A; rs2236225) is associated with increased risk for bipolar disorder and schizophrenia, neural tube and other birth defects. Mice homozygous for a loss of Mthfd1 via a gene-trap mutation are not viable, and heterozygotes, though they appear healthy, have metabolic imbalances in the folate- and choline-mediated 1-carbon metabolic pathways. In this study, we evaluated cognitive function in Mthfd1gt/+ male and female mice using a behavioral battery composed of eight different tests. We found that these mice display impaired cue-conditioned learning, while other behaviors remain intact. |
