| First Author | Takeo M | Year | 2023 |
| Journal | Nat Commun | Volume | 14 |
| Issue | 1 | Pages | 4478 |
| PubMed ID | 37542032 | Mgi Jnum | J:347045 |
| Mgi Id | MGI:7517625 | Doi | 10.1038/s41467-023-39605-z |
| Citation | Takeo M, et al. (2023) Cyclical dermal micro-niche switching governs the morphological infradian rhythm of mouse zigzag hair. Nat Commun 14(1):4478 |
| abstractText | Biological rhythms are involved in almost all types of biological processes, not only physiological processes but also morphogenesis. Currently, how periodic morphological patterns of tissues/organs in multicellular organisms form is not fully understood. Here, using mouse zigzag hair, which has 3 bends, we found that a change in the combination of hair progenitors and their micro-niche and subsequent bend formation occur every three days. Chimeric loss-of-function and gain-of-function of Ptn and Aff3, which are upregulated immediately before bend formation, resulted in defects in the downward movement of the micro-niche and the rhythm of bend formation in an in vivo hair reconstitution assay. Our study demonstrates the periodic change in the combination between progenitors and micro-niche, which is vital for the unique infradian rhythm. |
