| First Author | Waterhouse P | Year | 1995 |
| Journal | Science | Volume | 270 |
| Issue | 5238 | Pages | 985-8 |
| PubMed ID | 7481803 | Mgi Jnum | J:29652 |
| Mgi Id | MGI:77177 | Doi | 10.1126/science.270.5238.985 |
| Citation | Waterhouse P, et al. (1995) Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4 [see comments]. Science 270(5238):985-8 |
| abstractText | The role of the cell-surface molecule CTLA-4 in the regulation of T cell activation has been controversial. Here, lymph nodes and spleens of CTLA-4-deficient mice accumulated T cell blasts with up-regulated activation markers. These blast cells also infiltrated liver, heart, lung, and pancreas tissue, and amounts of serum immunoglobulin were elevated. The mice invariably became moribund by 3 to 4 weeks of age. Although CTLA-4-deficient T cells proliferated spontaneously and strongly when stimulated through the T cell receptor, they were sensitive to cell death induced by cross-linking of the Fas receptor and by gamma irradiation. Thus, CTLA-4 acts as a negative regulator of T cell activation and is vital for the control of lymphocyte homeostasis. |
