| First Author | Lobo MK | Year | 2013 |
| Journal | J Neurosci | Volume | 33 |
| Issue | 47 | Pages | 18381-95 |
| PubMed ID | 24259563 | Mgi Jnum | J:248628 |
| Mgi Id | MGI:6093857 | Doi | 10.1523/JNEUROSCI.1875-13.2013 |
| Citation | Lobo MK, et al. (2013) DeltaFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli. J Neurosci 33(47):18381-95 |
| abstractText | The transcription factor, DeltaFosB, is robustly and persistently induced in striatum by several chronic stimuli, such as drugs of abuse, antipsychotic drugs, natural rewards, and stress. However, very few studies have examined the degree of DeltaFosB induction in the two striatal medium spiny neuron (MSN) subtypes. We make use of fluorescent reporter BAC transgenic mice to evaluate induction of DeltaFosB in dopamine receptor 1 (D1) enriched and dopamine receptor 2 (D2) enriched MSNs in ventral striatum, nucleus accumbens (NAc) shell and core, and in dorsal striatum (dStr) after chronic exposure to several drugs of abuse including cocaine, ethanol, Delta(9)-tetrahydrocannabinol, and opiates; the antipsychotic drug, haloperidol; juvenile enrichment; sucrose drinking; calorie restriction; the serotonin selective reuptake inhibitor antidepressant, fluoxetine; and social defeat stress. Our findings demonstrate that chronic exposure to many stimuli induces DeltaFosB in an MSN-subtype selective pattern across all three striatal regions. To explore the circuit-mediated induction of DeltaFosB in striatum, we use optogenetics to enhance activity in limbic brain regions that send synaptic inputs to NAc; these regions include the ventral tegmental area and several glutamatergic afferent regions: medial prefrontal cortex, amygdala, and ventral hippocampus. These optogenetic conditions lead to highly distinct patterns of DeltaFosB induction in MSN subtypes in NAc core and shell. Together, these findings establish selective patterns of DeltaFosB induction in striatal MSN subtypes in response to chronic stimuli and provide novel insight into the circuit-level mechanisms of DeltaFosB induction in striatum. |
