| First Author | Sarter K | Year | 2016 |
| Journal | J Exp Med | Volume | 213 |
| Issue | 2 | Pages | 177-87 |
| PubMed ID | 26809444 | Mgi Jnum | J:232636 |
| Mgi Id | MGI:5779744 | Doi | 10.1084/jem.20150435 |
| Citation | Sarter K, et al. (2016) Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes. J Exp Med 213(2):177-87 |
| abstractText | Evidence has recently emerged that butyrophilins, which are members of the extended B7 family of co-stimulatory molecules, have diverse functions in the immune system. We found that the human and mouse genes encoding butyrophilin-2A2 (BTN2A2) are regulated by the class II trans-activator and regulatory factor X, two transcription factors dedicated to major histocompatibility complex class II expression, suggesting a role in T cell immunity. To address this, we generated Btn2a2-deficient mice. Btn2a2(-/-) mice exhibited enhanced effector CD4(+) and CD8(+) T cell responses, impaired CD4(+) regulatory T cell induction, potentiated antitumor responses, and exacerbated experimental autoimmune encephalomyelitis. Altered immune responses were attributed to Btn2a2 deficiency in antigen-presenting cells rather than T cells or nonhematopoietic cells. These results provide the first genetic evidence that BTN2A2 is a co-inhibitory molecule that modulates T cell-mediated immunity. |
