| First Author | Csencsits KL | Year | 2001 |
| Journal | J Immunol | Volume | 167 |
| Issue | 5 | Pages | 2441-5 |
| PubMed ID | 11509580 | Mgi Jnum | J:93848 |
| Mgi Id | MGI:3505836 | Doi | 10.4049/jimmunol.167.5.2441 |
| Citation | Csencsits KL, et al. (2001) Cutting edge: dichotomy of homing receptor dependence by mucosal effector B cells: alpha(E) versus L-selectin. J Immunol 167(5):2441-5 |
| abstractText | The common mucosal immune system may be compartmentalized because lymphocyte homing to the upper respiratory tract appears to be mediated by L-selectin interactions rather than alpha(4)beta(7) interactions, as is the case for gut-associated lymphoreticular tissue. To assess the role of L-selectin in effector B cell immunity, L-selectin-deficient mice were intranasally immunized with cholera toxin (CT), and mucosal immune responses were compared with C57BL/6 mice. The absence of L-selectin correlated with a reduction in CT-specific secretory-IgA responses in nasal passages and reproductive tract, but not intestinal lamina propria. Cell sorting experiments showed that an L-selectin-dependent subset was responsible for CT-specific responses in nasal passages and reproductive tract, whereas an alpha(E)beta(7)(+) B cell subset was responsible for L-selectin-independent intestinal immunity. This study provides evidence for compartmentalization of the common mucosal immune system into 'intestinal' vs 'nonintestinal' effector sites. |
