| First Author | Ramos-Prats A | Year | 2024 |
| Journal | Mol Psychiatry | Volume | 29 |
| Issue | 9 | Pages | 2774-2786 |
| PubMed ID | 38575807 | Mgi Jnum | J:359487 |
| Mgi Id | MGI:7788294 | Doi | 10.1038/s41380-024-02541-5 |
| Citation | Ramos-Prats A, et al. (2024) Loss of mGlu(5) receptors in somatostatin-expressing neurons alters negative emotional states. Mol Psychiatry 29(9):2774-2786 |
| abstractText | Subtype 5 metabotropic glutamate receptors (mGlu(5)) are known to play an important role in regulating cognitive, social and valence systems. However, it remains largely unknown at which circuits and neuronal types mGlu(5) act to influence these behavioral domains. Altered tissue- or cell-specific expression or function of mGlu(5) has been proposed to contribute to the exacerbation of neuropsychiatric disorders. Here, we examined how these receptors regulate the activity of somatostatin-expressing (SST+) neurons, as well as their influence on behavior and brain rhythmic activity. Loss of mGlu(5) in SST+ neurons elicited excitatory synaptic dysfunction in a region and sex-specific manner together with a range of emotional imbalances including diminished social novelty preference, reduced anxiety-like behavior and decreased freezing during retrieval of fear memories. In addition, the absence of mGlu(5) in SST+ neurons during fear processing impaired theta frequency oscillatory activity in the medial prefrontal cortex and ventral hippocampus. These findings reveal a critical role of mGlu(5) in controlling SST+ neurons excitability necessary for regulating negative emotional states. |
