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Allele : Gt(ROSA)26Sor<tm2(SNCA*119)Djmo> gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Darren Moore
Primary Identifier  MGI:3840596 Allele Type  Targeted
Attribute String  Conditional ready, Humanized sequence, Inserted expressed sequence Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  129
Is Recombinase  false Is Wild Type  false
description  The original refernece states that 129/SvJ-derived embryonic stem cells were used.
molecularNote  A targeting vector was designed with an SV40 splice acceptor, a loxP-flanked STOP cassette (PGK-neo and triple SV40 transcriptional termination sequence), a cDNA encoding the 119 amino acid C-terminal truncation of human alpha-synuclein associated with familial Parkinson's disease (Syn119 or SynCT119; encoding amino acids 1-119 of the full length protein), and a bovine polyadenylation signal.
  • mutations:
  • Insertion
  • synonyms:
  • ROSA26-a-synuclein C-terminal truncation variant (Syn119),
  • ROSA26-a-synuclein C-terminal truncation variant (Syn119),
  • ROSA26-Syn119,
  • ROSA26-SynCT119<Tg>,
  • ROSA26-Syn119,
  • ROSA26-SynCT119<Tg>
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0 Mutation Involves

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