| First Author | Otsu Y | Year | 2015 |
| Journal | Nat Neurosci | Volume | 18 |
| Issue | 2 | Pages | 210-8 |
| PubMed ID | 25531572 | Mgi Jnum | J:283992 |
| Mgi Id | MGI:6386016 | Doi | 10.1038/nn.3906 |
| Citation | Otsu Y, et al. (2015) Calcium dynamics in astrocyte processes during neurovascular coupling. Nat Neurosci 18(2):210-8 |
| abstractText | Enhanced neuronal activity in the brain triggers a local increase in blood flow, termed functional hyperemia, via several mechanisms, including calcium (Ca(2+)) signaling in astrocytes. However, recent in vivo studies have questioned the role of astrocytes in functional hyperemia because of the slow and sparse dynamics of their somatic Ca(2+) signals and the absence of glutamate metabotropic receptor 5 in adults. Here, we reexamined their role in neurovascular coupling by selectively expressing a genetically encoded Ca(2+) sensor in astrocytes of the olfactory bulb. We show that in anesthetized mice, the physiological activation of olfactory sensory neuron (OSN) terminals reliably triggers Ca(2+) increases in astrocyte processes but not in somata. These Ca(2+) increases systematically precede the onset of functional hyperemia by 1-2 s, reestablishing astrocytes as potential regulators of neurovascular coupling. |
