| First Author | Teng TS | Year | 2012 |
| Journal | J Clin Invest | Volume | 122 |
| Issue | 12 | Pages | 4447-60 |
| PubMed ID | 23160199 | Mgi Jnum | J:193971 |
| Mgi Id | MGI:5469996 | Doi | 10.1172/JCI63120 |
| Citation | Teng TS, et al. (2012) Viperin restricts chikungunya virus replication and pathology. J Clin Invest 122(12):4447-60 |
| abstractText | Chikungunya virus (CHIKV) is a mosquito-borne arthralgia arbovirus that is reemergent in sub-Saharan Africa and Southeast Asia. CHIKV infection has been shown to be self-limiting, but the molecular mechanisms of the innate immune response that control CHIKV replication remain undefined. Here, longitudinal transcriptional analyses of PBMCs from a cohort of CHIKV-infected patients revealed that type I IFNs controlled CHIKV infection via RSAD2 (which encodes viperin), an enigmatic multifunctional IFN-stimulated gene (ISG). Viperin was highly induced in monocytes, the major target cell of CHIKV in blood. Anti-CHIKV functions of viperin were dependent on its localization in the ER, and the N-terminal amphipathic alpha-helical domain was crucial for its antiviral activity in controlling CHIKV replication. Furthermore, mice lacking Rsad2 had higher viremia and severe joint inflammation compared with wild-type mice. Our data demonstrate that viperin is a critical antiviral host protein that controls CHIKV infection and provide a preclinical basis for the design of effective control strategies against CHIKV and other reemerging arthrogenic alphaviruses. |
