Primary Identifier | MGI:3845256 | Allele Type | Targeted |
Attribute String | Conditional ready, Dominant negative | Gene | Prkar1a |
Transmission | Germline | Strain of Origin | 129X1/SvJ |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A point mutation results in the amino acid substitution of alanine for glycine at position 324 (G324A) encoded by exon 11. A floxed neo cassette upsteam of exon 11 prevents expression of the dominant negative mutation except following cre mediated removal of the cassette. |