| First Author | Eisele PS | Year | 2015 |
| Journal | Biochem Biophys Res Commun | Volume | 464 |
| Issue | 3 | Pages | 692-7 |
| PubMed ID | 26159922 | Mgi Jnum | J:228767 |
| Mgi Id | MGI:5708806 | Doi | 10.1016/j.bbrc.2015.06.166 |
| Citation | Eisele PS, et al. (2015) The PGC-1 coactivators promote an anti-inflammatory environment in skeletal muscle in vivo. Biochem Biophys Res Commun 464(3):692-7 |
| abstractText | The peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) is abundantly expressed in trained muscles and regulates muscle adaptation to endurance exercise. Inversely, mice lacking a functional PGC-1alpha allele in muscle exhibit reduced muscle functionality and increased inflammation. In isolated muscle cells, PGC-1alpha and the related PGC-1beta counteract the induction of inflammation by reducing the activity of the nuclear factor kappaB (NFkappaB). We now tested the effects of these metabolic regulators on inflammatory reactions in muscle tissue of control and muscle-specific PGC-1alpha/-1beta transgenic mice in vivo in the basal state as well as after an acute inflammatory insult. Surprisingly, we observed a PGC-1-dependent alteration of the cytokine profile characterized by an increase in anti-inflammatory factors and a strong suppression of the pro-inflammatory interleukin 12 (IL-12). In conclusion, the anti-inflammatory environment in muscle that is promoted by the PGC-1s might contribute to the beneficial effects of these coactivators on muscle function and provides a molecular link underlying the tight mutual regulation of metabolism and inflammation. |
