| First Author | Spitzer SO | Year | 2019 |
| Journal | Neuron | Volume | 101 |
| Issue | 3 | Pages | 459-471.e5 |
| PubMed ID | 30654924 | Mgi Jnum | J:279523 |
| Mgi Id | MGI:6281823 | Doi | 10.1016/j.neuron.2018.12.020 |
| Citation | Spitzer SO, et al. (2019) Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age. Neuron 101(3):459-471.e5 |
| abstractText | Oligodendrocyte progenitor cells (OPCs), which differentiate into myelinating oligodendrocytes during CNS development, are the main proliferative cells in the adult brain. OPCs are conventionally considered a homogeneous population, particularly with respect to their electrophysiological properties, but this has been debated. We show, by using single-cell electrophysiological recordings, that OPCs start out as a homogeneous population but become functionally heterogeneous, varying both within and between brain regions and with age. These electrophysiological changes in OPCs correlate with the differentiation potential of OPCs; thus, they may underlie the differentiational differences in OPCs between regions and, likewise, differentiation failure with age. |
