| First Author | Burkhardt U | Year | 2014 |
| Journal | Neurosci Lett | Volume | 572 |
| Pages | 48-52 | PubMed ID | 24813107 |
| Mgi Jnum | J:214336 | Mgi Id | MGI:5588778 |
| Doi | 10.1016/j.neulet.2014.04.052 | Citation | Burkhardt U, et al. (2014) Impaired brain development and reduced cognitive function in phospholipase D-deficient mice. Neurosci Lett 572:48-52 |
| abstractText | The phospholipases D (PLD1 and 2) are signaling enzymes that catalyze the hydrolysis of phosphatidylcholine to phosphatidic acid, a lipid second messenger involved in cell proliferation, and choline, a precursor of acetylcholine (ACh). In the present study, we investigated development and cognitive function in mice that were deficient for PLD1, or PLD2, or both. We found that PLD-deficient mice had reduced brain growth at 14-27 days post partum when compared to wild-type mice. In adult PLD-deficient mice, cognitive function was impaired in social and object recognition tasks. Using brain microdialysis, we found that wild-type mice responded with a 4-fold increase of hippocampal ACh release upon behavioral stimulation in the open field, while PLD-deficient mice released significantly less ACh. These results may be relevant for cognitive dysfunctions observed in fetal alcohol syndrome and in Alzheimer' disease. |
