| First Author | Lang Y | Year | 2024 |
| Journal | iScience | Volume | 27 |
| Issue | 7 | Pages | 110205 |
| PubMed ID | 39055928 | Mgi Jnum | J:352031 |
| Mgi Id | MGI:7704769 | Doi | 10.1016/j.isci.2024.110205 |
| Citation | Lang Y, et al. (2024) Monoacylglycerol acyltransferase-2 inhibits colorectal carcinogenesis in APC(min+/-) mice. iScience 27(7):110205 |
| abstractText | Monoacylglycerol acyltransferase-2 (MOGAT2), encodes MOGAT enzyme in the re-synthesis of triacylglycerol and protects from metabolism disorders. While, its precise involvement in colorectal cancer (CRC) progression remains inadequately understood. Our study demonstrated that knockout of Mogat2 in Apc(min/+) mice expedited intestinal tumor growth and progression, indicating that Mogat2 plays a tumor-suppressing role in CRC. Mechanically, Mogat2 deletion resulted in a significant alter the gut microbiota, while Fecal Microbiota Transplantation (FMT) experiments demonstrated that the gut microbiota in Mogat2 deleted mice promoted tumor growth. Furthermore, we identified Mogat2 as a functional regulator suppressing CRC cell proliferation and tumor growth by inhibiting the NF-kappaB signaling pathway in vivo. Collectively, these results provide novel insights into the protective double roles of Mogat2, inhibiting of NF-kappaB pathway and keeping gut microbiota homeostasis in colorectal cancer, which may help the development of novel cancer treatments for CRC. |
