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Allele : Arhgef12<tm1.1Wet> Rho guanine nucleotide exchange factor 12; targeted mutation 1.1, Nina Wettschureck

Primary Identifier  MGI:3849180 Allele Type  Targeted
Attribute String  Conditional ready, No functional change Gene  Arhgef12
Transmission  Germline Strain of Origin  129
Is Recombinase  false Is Wild Type  false
molecularNote  Exons 16-18 of Arhgef12 were flanked with loxP sites with a frt-flanked neomycin cassette inserted for targeting purposes. The neomycin cassette was later deleted by crossing with Flpe transgenic mice. Gene expression was unaffected as determined by western blotting of cortex lysates. Upon expression of cre recombinase, a null allele is created.
  • mutations:
  • Insertion
  • synonyms:
  • LARG<fl>,
  • LARG<fl>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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0 Driven By

7 Publication categories

Trail: Allele