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Publication : Identification of transcriptional regulators in the mouse immune system.

First Author	Jojic V	Year	2013
Journal	Nat Immunol	Volume	14
Issue	6	Pages	633-43
PubMed ID	23624555	Mgi Jnum	J:260613
Mgi Id	MGI:6142653	Doi	10.1038/ni.2587
Citation	Jojic V, et al. (2013) Identification of transcriptional regulators in the mouse immune system. Nat Immunol 14(6):633-43

abstractText

The differentiation of hematopoietic stem cells into cells of the immune system has been studied extensively in mammals, but the transcriptional circuitry that controls it is still only partially understood. Here, the Immunological Genome Project gene-expression profiles across mouse immune lineages allowed us to systematically analyze these circuits. To analyze this data set we developed Ontogenet, an algorithm for reconstructing lineage-specific regulation from gene-expression profiles across lineages. Using Ontogenet, we found differentiation stage-specific regulators of mouse hematopoiesis and identified many known hematopoietic regulators and 175 previously unknown candidate regulators, as well as their target genes and the cell types in which they act. Among the previously unknown regulators, we emphasize the role of ETV5 in the differentiation of gammadelta T cells. As the transcriptional programs of human and mouse cells are highly conserved, it is likely that many lessons learned from the mouse model apply to humans.

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52 Authors

Monach P,
Randolph GJ,
Lanier LL,
Blair DA,
Dustin ML,
Laidlaw D,
Collins J,
Ericson J,
Sylvia K,
Kim CC,
Brenner M,
Joic V,
Mathis D,
Malhotra D,
Koller D,
Kim F,
Best AJ,
Turley S,
Shay T,
Shinton SA,
Sun JC,
Zuk O,
Goldrath A,
Elpek K,
Sun X,
Brennan P,
Kang J,
Jakubzick C,
Rossi DJ,
Regev A,
Rothamel K,
Gautier EL,
Brown B,
Merad M,
Malhotra N,
Immunological Genome Project Consortium.,
Heng T,
Knell J,
Fletcher A,
Jojic V,
Rao TN,
Gazit R,
Kreslavsky T,
Bellemarte-Pelletier A,
Benoist C,
Cohen N,
Hardy RR,
Bezman NA,
Wagers A,
Ortiz-Lopez A,
Miller J,
Min-Oo G

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