| Primary Identifier | MGI:3851796 | Allele Type | Transgenic |
| Attribute String | Dominant negative, Inserted expressed sequence | Gene | Tg(Myh6-Mapk8*,Myh6-Mapk9*)22.4Jmol |
| Strain of Origin | FVB/N | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Dominant negative JNK1 (Mapk8) and JNK2 (Mapk9) cDNAs in which the dual phosphorylation motif TPY was changed to APF were each fused to a 5.5 kb cardiac specific alpha myosin heavy chain promoter. The constructs were mixed and coinjected into FVB/N oocytes. Three independent lines including 22.4 which was chosen as a representative, and 6.1 were found to coexpress equal amounts of each dominant negative protein. |
