Primary Identifier | MGI:3851439 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Pde4a |
Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The targeting vector was designed to replace exons 9-14 and part of exon 15, which encode the entire predicted catalytic domain, with a floxed neomycin cassette. Founder mice were crossed with cre transgenic mice to remove the neomycin cassette. No protein product was detected in homozygote olfactory epithelium as determined by immunohistochemistry. |