| First Author | Kim JK | Year | 2010 |
| Journal | Hum Mol Genet | Volume | 19 |
| Issue | 3 | Pages | 445-53 |
| PubMed ID | 19897589 | Mgi Jnum | J:155312 |
| Mgi Id | MGI:4413495 | Doi | 10.1093/hmg/ddp509 |
| Citation | Kim JK, et al. (2010) Overexpression of Hr links excessive induction of Wnt signaling to Marie Unna hereditary hypotrichosis. Hum Mol Genet 19(3):445-53 |
| abstractText | Marie Unna hereditary hypotrichosis (MUHH) is a rare autosomal dominant hair disorder. Through the study of a mouse model, we identified a mutation in the 5'-untranslated region of the hairless (HR) gene in patients with MUHH in a Caucasian family. The corresponding mutation, named 'hairpoor', was found in mutant mice that were generated through N-ethyl-N-nitrosourea mutagenesis. Hairpoor mouse mutants display partial hair loss at an early age and progress to near alopecia, which resembles the MUHH phenotype. This mutation conferred overexpression of HR through translational derepression and, in turn, decreased the expression of Sfrp2, an inhibitor of the Wnt signaling pathway. This study indicates that the gain in function of HR also results in alopecia, as seen with the loss of function of HR, via abnormal upregulation of the Wnt signaling pathway. |
