| First Author | Connell M | Year | 2017 |
| Journal | Elife | Volume | 6 |
| PubMed ID | 28994651 | Mgi Jnum | J:255775 |
| Mgi Id | MGI:6114430 | Doi | 10.7554/eLife.28672 |
| Citation | Connell M, et al. (2017) HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development. Elife 6:e28672 |
| abstractText | Oriented cell division is one mechanism progenitor cells use during development and to maintain tissue homeostasis. Common to most cell types is the asymmetric establishment and regulation of cortical NuMA-dynein complexes that position the mitotic spindle. Here, we discover that HMMR acts at centrosomes in a PLK1-dependent pathway that locates active Ran and modulates the cortical localization of NuMA-dynein complexes to correct mispositioned spindles. This pathway was discovered through the creation and analysis of Hmmr-knockout mice, which suffer neonatal lethality with defective neural development and pleiotropic phenotypes in multiple tissues. HMMR over-expression in immortalized cancer cells induces phenotypes consistent with an increase in active Ran including defects in spindle orientation. These data identify an essential role for HMMR in the PLK1-dependent regulatory pathway that orients progenitor cell division and supports neural development. |
