| Primary Identifier | MGI:6280324 | Allele Type | Targeted |
| Gene | Grin2b | Transmission | Germline |
| Strain of Origin | 129P2/OlaHsd | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Three mutations, a leucine to alanine at amino acid 1298, an arginine to asparagine at amino acid 1300, and a serine to aspartate at amino acid 1303 (L1298A/R1300N/S1303D), were introduced in the CTD2B sub-region, and a loxP-flanked neomycin phosphotransferase gene driven by a compound phosphoglycerate kinase (PGK) and EM7 promoter was inserted. The mutations abrogate CaMKII binding to Grin2b. Cre-mediated recombination removed the neo cassette. |
