| First Author | Chen Y | Year | 2022 |
| Journal | FEBS Lett | Volume | 596 |
| Issue | 11 | Pages | 1434-1444 |
| PubMed ID | 35294049 | Mgi Jnum | J:329535 |
| Mgi Id | MGI:7344032 | Doi | 10.1002/1873-3468.14335 |
| Citation | Chen Y, et al. (2022) Adipocyte-specific CDK7 ablation leads to progressive loss of adipose tissue and metabolic dysfunction. FEBS Lett 596(11):1434-1444 |
| abstractText | Adipose tissue regulates whole-body energy homeostasis. Both lipodystrophy and obesity, the extreme and opposite aspects of adipose tissue dysfunction, result in metabolic disorders: insulin resistance and hepatic steatosis. Cyclin-dependent kinases (CDKs) have been reported to be involved in adipose tissue development and functions. Using adipose tissue-specific knockout mice, here we demonstrate that the deletion of CDK7 in adipose tissue results in progressive lipodystrophy, insulin resistance, impaired adipokine secretion and downregulation of fat-specific genes, which are aggravated on high-fat diet and during ageing. Our studies suggest that CDK7 is a key regulatory component of adipose tissue maintenance and systemic energy homeostasis. |
